SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME AMIDE DERIVATIVES
Abstract:
<p align="justify"> A series of amide derivates have been synthesized through the one-pot method by condensing appropriate 4-oxo-4-(4-substituted phenyl_butanoic acid moiety with isoniazid. The amides have been evaluated for their antimicrobial activity (Minimum Inhibitory Concentration - MIC) against Bacillus Sbtilis, Klebsiella pneumonie, and Candida albicans. Once compound, 2b, was found to have significant antimicrobial activity. </p>
<p align="justify"> A series of amide derivates have been synthesized through the one-pot method by condensing appropriate 4-oxo-4-(4-substituted phenyl_butanoic acid moiety with isoniazid. The amides have been evaluated for their antimicrobial activity (Minimum Inhibitory Concentration - MIC) against Bacillus Sbtilis, Klebsiella pneumonie, and Candida albicans. Once compound, 2b, was found to have significant antimicrobial activity. </p>
DOI: 10.48141/SBJCHEM.v18.n18.2010.32_2010.pdf
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