ANTITUBERCULAR ACTIVITY OF SOME NEWER 6-PYRIDAZINONE DERIVATIVES
Abstract:
<p align="justify"> Two series of 6-pyridazinone derivatives (17-30) were synthesized and evaluated for antitubercular activities against Mycobacterium tuberculosis H<sub>37</sub>R<sub>v</sub> strain. The results indicated that among the synthesized compounds, 5-( 4-hydroxy-3-methoxybenzyl}-3-phenyl-1,6-dihydro-6-pyridazinone (23) showed good antitubercular activity. Three more compounds, (18, 25 & 27) were significant in their antitubercular action. The present study reveals the antitubercular potential of 6-pyridazinones. </p>
<p align="justify"> Two series of 6-pyridazinone derivatives (17-30) were synthesized and evaluated for antitubercular activities against Mycobacterium tuberculosis H<sub>37</sub>R<sub>v</sub> strain. The results indicated that among the synthesized compounds, 5-( 4-hydroxy-3-methoxybenzyl}-3-phenyl-1,6-dihydro-6-pyridazinone (23) showed good antitubercular activity. Three more compounds, (18, 25 & 27) were significant in their antitubercular action. The present study reveals the antitubercular potential of 6-pyridazinones. </p>
DOI: 10.48141/SBJCHEM.v19.n19.2011.22_2011.pdf
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