Abstract:
<p align="justify"> The aim of this study has been to design a useful drug, which may act with effectiveness both on the gram-positive and gram-negative bacteria (broad-spectrum). An amide-based mutual prodrug (NA-SN) was been prepared following a single-step synthesis by condensing sulfanilamide with nalidixic acid. The compound (NA-SN) was evaluated for in-vitro antibacterial activity against some selected bacteria with significant results. Hydrolysis kinetics of the mutual prodrug were also studied in acidic and basic buffers. The present study reveals the pharmaceutical potential of mutual prodrugs. </p>