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BIOLOGICAL ACTIVE ACYLHYDRAZIDE I. THE O-ACYL-DERIVATIVES NATURE OF MONOACYLATION PRODUCTS OF CYCLIC MALEIC- AND PHTHALIC-HYDRAZIDE
Volume: 7
Number: 8
Year: 1999
Pages: 25-40
I Panea, Lucia Bodochi, Teodora Panea, Daniela Zinveliu and Violeta Pascalau
Abstract:
<p align="justify"> We confirmed, on the basis of chemical and physicochemical (melting points, IR- and 1H-NMR-spectra) data, that the products isolated by monoacylation of cyclic maleic- and phthalic-hydrazides have only the O-acyl derivatives nature although owing to tautomerism. These hydrazides may give rise to N- or/and O-acyl derivatives in such reactions. Simultaneously, we showed that the claims for the obtainment of N-acyl derivatives of cyclic maleic- and phthalic-hydrazides were not valid. Also by reacting the cyclic maleic-, respectively phthalic-hydrazide, with 4-chlorobenzoylchloride two new O-monoacylderivatives [3-( 4-chlorobenzoyloxy)-l-H-pyridazin-6-one and 1-(4-chlorobenzoyloxy)-3-H-phthalazin-l-one] were obtained </p>
DOI: 10.48141/SBJCHEM.v7.n8.1999.27_1999.pdf
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