Latest Edition Highlights (Issue 39)

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FROM AIR FORCE TO HYPERSONIC FUTURE: ÉLCIO GERÔNIMO DE OLIVEIRA'S JOURNEY IN BRAZILIAN AEROSPACE DEVELOPMENT (ENGLISH VERSION)

Introdução: A entrevista com Élcio Gerônimo de Oliveira, conduzida pelo repórter Luis, apresenta a trajetória profissional de um pesquisador brasileiro com experiência na Força Aérea Brasileira e no meio acadêmico, com foco em sistemas espaciais e veículos hipersônicos. Objetivos: Documentar a carreira e contribuições de Élcio para o desenvolvimento aeroespacial brasileiro, destacando sua transição da carreira militar para a acadêmica e sua participação em projetos estratégicos, especialmente o projeto 14X. Métodos: A entrevista foi estruturada em blocos temáticos, abordando a carreira militar, a experiência acadêmica e, com maior detalhamento, o envolvimento no projeto do veículo hipersônico 14X. Foram realizadas perguntas abertas, permitindo ao entrevistado compartilhar sua experiência e conhecimento técnico. Resultados: Élcio descreveu sua progressão na Força Aérea Brasileira, desde pesquisador até vice-chefe da Diretoria de Espaço, destacando o desenvolvimento de veículos lançadores, sistemas de navegação inercial e o projeto SARA. Relatou sua transição para a carreira acadêmica, incluindo sua experiência como professor na Universidade de Luleå, na Suécia. Élcio detalhou sua coordenação no projeto 14X, um veículo hipersônico que alcançou Mach 7, com perspectivas de atingir Mach 10. Discussão: A entrevista revela a importância da cooperação internacional e da transferência de tecnologia, exemplificada pela doação do primeiro laboratório de hipersônica do Brasil. Evidencia também os desafios técnicos na construção de veículos hipersônicos e o potencial dessas tecnologias para aplicações militares e civis. Conclusão: A carreira de Élcio Gerônimo de Oliveira exemplifica a contribuição brasileira para pesquisa aeroespacial avançada, demonstrando a capacidade nacional de desenvolver tecnologias estratégicas como veículos hipersônicos, apesar das limitações de recursos, e apontando possibilidades futuras para o transporte e exploração espacial.
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TREATMENTS FOR ACUTE LYMPHOBLASTIC LEUKEMIA: A COMPARISON BETWEEN TISAGENLECLEUCEL AND CLOFARABINE

Background: Acute lymphoblastic leukemia (ALL) is a heterogeneous hematological malignancy predominantly affecting individuals under 20 years of age. Traditional chemotherapy, such as clofarabine, has shown efficacy; however, novel immunotherapeutic strategies like tisagenlecleucel (Kymriah®) have significantly altered the treatment paradigm. Aim: This study aimed to perform a comparative analysis of tisagenlecleucel, a CAR-T cell therapy, and clofarabine, a second-generation purine nucleoside analog, evaluating their mechanisms of action, therapeutic benefits, limitations, and clinical applicability across diverse patient populations. Methods: A systematic comparative evaluation was conducted, encompassing pharmacological characteristics, mechanisms of action, treatment protocols, efficacy, safety profiles, and clinical indications of both agents. The analysis considered pharmacokinetic and pharmacodynamic data and included patient demographic variables. Results: Tisagenlecleucel demonstrated high efficacy in refractory B-cell ALL, with durable responses and a blood half-life of 128 days, but with notable immune-related adverse effects such as cytokine release syndrome. Clofarabine, effective across a broader patient population, acts via multiple antitumor mechanisms but carries significant toxicity risks, including infection and sepsis. Discussion: The therapies present distinct clinical profiles: tisagenlecleucel offers targeted immunotherapy with high specificity but requires specialized infrastructure and management of immune toxicities. Clofarabine is more widely accessible and applicable, but is associated with conventional chemotherapy-related side effects. Treatment accessibility and cost differ markedly between the two. Conclusions: Therapy selection should be personalized based on patient-specific factors and institutional resources. Tisagenlecleucel is ideal for pediatric and young adult patients with relapsed/refractory B-cell ALL in CAR-T-capable centers, while clofarabine remains a viable option for broader ALL populations, particularly when genetic therapies are not feasible. Further research is needed to optimize therapeutic strategies and improve access to advanced treatments.
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INTERVIEW WITH DEPUTY VICE CHANCELLOR DR. O. A. OMOTESHO, UNIVERSITY OF ILORIN, NIGERIA (ENGLISH VERSION)

Background: The University of Ilorin, founded in 1975 in Nigeria, has evolved from 3 to 16 faculties, becoming the country's most sought-after institution for the past two decades. Aims: To document the institutional evolution, identify the most demanded programs, assess scientific output, examine internationalization strategies, and understand strategic development objectives. Methods: Structured interview with Vice-Chancellor Dr. Olubumi Abayomi Omotesho, following a standardized protocol covering historical, academic, scientific, and strategic aspects of the institution, under Creative Commons license format. Results: The university expanded to 16 faculties in 49 years. The most demanded programs are Medicine and Nursing, followed by Pharmacy, Law, Engineering, and Accounting. Areas with the highest scientific output: Medicine, Biological/Agricultural Sciences, and Engineering. It offers 340 postgraduate programs with approximately 7,523 students. There is a dedicated infrastructure for internationalization, with plans for international accommodations. Discussion: The predominance of healthcare courses reflects global employability trends. Research aligned with Sustainable Development Goals demonstrates a contemporary vision. The institutional goal (number one in Nigeria, top 10 in Africa, top 500 globally) shows a measurable strategic approach. Commitment to internationalization aligns with global education trends. Conclusions: The institution exemplifies an evolving African university focused on academic excellence, scientific relevance, and internationalization. The prioritization of student-centered development, clear positioning goals, and international collaboration initiatives establish solid foundations for its contribution to regional and global knowledge.
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General information

SOUTHERN JOURNAL OF SCIENCES

    General information about this journal
  • Title: SOUTHERN JOURNAL OF SCIENCES
  • Short Title: South. J. Sci.
  • ISSN: 2764-5959 (Online); ISSN: 2764-5967 (Print)
  • Universal Decimal Classification (UDC): 001
  • Review Process: Double-Blind Peer-Review
  • Accessibility: Platinum Open Access, NO-APCs.
  • Digital preservation: Portico
  • Frequency of Publication: biannual [2 issues per year]. Journal publication schedule
  • DOI: 10.48141/2764-5959
  • Website: https://www.sjofsciences.com/
  • Country: BRAZIL
  • Publisher: Araucária - Scientific Association.
  • Language of Publication: ENGLISH / PORTUGUESE*
  • *Year that the Journal started accepting manuscripts in Portuguese: 2020
  • First issue year: 1993
  • Free full text: Yes
  • Indexed in: Index Copernicus; Latindex, and I2OR.
  • Formerly known as the Southern Brazilian Journal of Chemistry (1993 to 2021).
  • Former ISSN: 2674-6891 (Online); Former ISSN: 0104-5431 (Print).
  • Website last update: 06/07/2025.

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SECOND SOUTHERN SCIENCE CONFERENCE - INTERNATIONAL SCIENTIFIC CONFERENCE – 2024

Background: Scientific conferences play a vital role in knowledge exchange and collaboration across disciplines. Building on the success of its 2022 inaugural event, the Second Southern Science Conference (SSCON 2024) aimed to expand international scientific collaboration while addressing contemporary challenges in sustainability and research methodology. Aims: To evaluate the effectiveness of a hybrid conference format in facilitating global scientific collaboration and to showcase cutting-edge research across multiple disciplines, with particular emphasis on sustainability and technological innovation in Latin America. Methods: The conference implemented a hybrid format combining in-person and virtual attendance. Over three days, 38 lectures were presented by renowned researchers, covering key topics including materials science, environmental sustainability, chemical processes, and regional development. Participation metrics and collaboration patterns were analyzed to assess the conference's impact. Results: The conference achieved significant participation with 242 contributing authors from 13 countries across four continents. Notable research presentations included advances in laser surface modification techniques, geotechnology applications in biofuel production, sustainable silica synthesis from biomass, and green valorization of tropical seeds. The conference produced 66 approved papers, with most involving 2-5 collaborators. Discussion: The hybrid format proved effective in removing geographical barriers and promoting global engagement. The strong representation from Latin American institutions highlighted the region's growing influence in international scientific discourse. Key research presentations demonstrated innovative approaches to sustainability challenges, particularly in waste utilization and environmental technology. Conclusion: SSCON 2024 successfully evolved from its predecessor, demonstrating the effectiveness of hybrid conferencing in fostering international scientific collaboration. The conference established itself as a vital platform for knowledge exchange, particularly in sustainability and technological innovation, while identifying areas for future improvement such as extended submission timelines and permanent management structures.
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MISUSE AND ABUSE OF DRUGS: A CROSS-SECTIONAL SURVEY AMONG PHARMACY PROFESSIONALS IN SAUDI ARABIA

Prescription and non-prescription medication misuse or abuse is a global problem that has a negative impact on all human life aspects, including health, social, economic, and security status. According to the United Nations Office on Drug and Crime reports, over 5% of adult people used drugs at least once in the year 2015, and 29.5 million of them were suffered from the consequences of inappropriate use of drugs. Information on the knowledge and perception among pharmacists regarding the misuse and abuse medications in Saudi Arabia are limited, and therefore, a study was conducted among pharmacy staff to assess their knowledge and awareness on drug misuse and abuse. A cross-sectional study was carried out in Eastern Province, Saudi Arabia. Pharmacy professionals with more than three months of experience were included in the study. A structured questionnaire was used to obtain the participant's responses. A Chi-square test was used to evaluate the association of sociodemographic factors with the participant's responses. Ninety pharmacy professionals were responded. Overall, 69 (76.7%) participants agreed that misuse and abuse are two different terms. In addition, the study showed different responses for patients who suspected to be medication abusers. In conclusion, this study provides an initial picture of pharmacy staffs' knowledge and opinion regarding the misuse and abuse of medicines in Saudi Arabia. Participants' reactions toward such behaviors were different and not consistent. Therefore, there should be a clear policy to define the role of the pharmacy staff toward the misuse and abuse of medication in Saudi Arabia.
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EFFECT OF MECHANICAL ACTIVATION ON THE POTASSIUM AVAILABILITY OF PHONOLITE ROCK

Background: Researchers are carried out to assess rocks containing potassium as an alternative source of fertilizers. These studies are important in reducing the external dependence of Brazil on this commodity. Phonolite is a rock of volcanic origin that has in its mineralogical composition the predominance of feldspar and has been potential to use as an alternative potassium source. The studied rock has 6% total-K but is unavailable to plants in natural rock. Aim: This project evaluated the effect of mechanical activation, wet and dry, on K availability for extractors different and its K leaching curves of phonolite from Poços de Caldas, MG, Brazil. Methods: Phonolite rock was subjected to mechanical activation for 30 and 60 min by wet and dry processes. Particle size distribution, XRD, and FTIR analyses characterized phonolite activated. These results were compared to the behavior of the rock with no activation. K availability (total; water-soluble; exchangeable, non-exchangeable, and structural) was determined in samples activated and no activation. K leaching curves were obtained by successive extractions with 0.01 mol L-1 citric acid and Mehlich-1 solutions to 1812 h and analyzed by FAAS. Results: The samples mechanical activation promoted a reduction in the intensity of the diffraction peaks. In the sample dry mechanical activation for 60 min, K released increased by 15% in relation to the no activation sample. K leaching curves were observed with similar behavior for the extractors and higher K availability after 235 h of total contact time. Discussion: Mechanical activation promoted a decrease in structural K and an increase in non-exchangeable K, released into the soil solution in the medium term. Since the mineralogical composition was not changed, the process action is more efficient in creating the structural defects suggested. K leaching curves corroborate these results, with a continuous and slow K released for a longer contact time. Conclusions: It was concluded that the phonolite activated by dry mechanical activation for 60 min increased K-released content compared with the wet process and ratified the possibility of the activated phonolite rock as a slow-release fertilizer.
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SOUTHERN JOURNAL OF SCIENCES

The SOUTHERN JOURNAL OF SCIENCES publishes articles in Chemistry, Physics, Mathematics, Biology, Pharmacy, Medicine, Engineering, Industrial Science, Agriculture, and related interdisciplinary areas and is intended to fill a gap in terms of scientific information worldwide. All manuscripts can be published either in English or Portuguese, with tile, abstracts, and keywords in English. At present, there are NO PUBLICATION FEES. Editors will cover web hosting, open access, DOI number, and other service costs.

We have set high standards for the articles to be published by ensuring strong but fair refereeing by at least two reviewers. We hope that this Journal will provide a forum for disseminating high-quality research in chemistry and related areas and are open to any questions and suggestions. Starting in 2020, the SOUTHERN JOURNAL OF SCIENCES will have two issues per year (June and December).

Thank you very much for choosing the SOUTHERN JOURNAL OF SCIENCES to publish your paper!
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