D-DIMER A RISK FACTOR ASSOCIATED WITH C-REACTIVE PROTEIN FOR PREDICTING THE SEVERITY OF INFECTION BY COVID-19
Background: COVID-19, caused by SARS-CoV-2, has unresolved mortality risk factors and clinical course, highlighting the need for further research. Aims: The study aimed to asses D-dimer and C-Reactive Protein (CRP) as the risk factors for severity covid-19 and who are less capable of surviving. Methods: A retrospective study conduct of COVID-19 in adult inpatients aged >20 at Al-sadder and Alamal Hospital in Iraq. Demographics, clinical trials, treatments, and viral RNA samples were analyzed. The study involved 100 patients, with 67 discharged and 33 hospitalized died. The majority of the participants 45% were aged < 40, but 55% were aged >40 years. Results: A significant and 57% were male 37(55.2%) Survivor vs. 20 (60.6%) non-survivor, p=0.024), more than 43% were female (30(44.8%) Survivor vs. 13(39.4%) non-survivor, p=0.010. Patients had underlying comorbidities (66%), survivor 37(55%), and non-survivor 29(87%). The most prominent comorbidity in non-survivors more than survivors was diabetic mellitus 85%, asthma 58%, stroke 48%, renal failure 42%, heart strake 33%, and hypertension 18%. The study found significant differences in WBC, lymphocyte count, D-dimer, Ferritin, CRP, and LDH levels in non-survivors compared to survivor patients, with a positive correlation between D- dimer and these parameters. The ROC analysis curve showed CRP with a high AUC of 80.2%, 87.9% sensitivity, and 37.3% specificity, while D-dimer and LDH had AUCs of 0.74.9 and 70%, respectively. Discussion: The study found that older age, higher d-dimer, ferritin, CRP, and LDH are associated with disease severity and higher mortality risk in adult COVID-19 patients. Conclusions: These biomarkers could aid in early detection of disease progression signs and better patient management
Read ArticleREVIEW ABOUT DIABETES MELLITUS AND URINARY TRACT INFECTIONS
Diabetes mellitus (DM) is a clinical disease correlated with a deficiency of insulin secretion or action.It is one of the leading causes of morbidity and mortality worldwide. The global burden of diabetes is rising dueto increasing obesity and population aging. Urinary tract infections (UTI) are common microbial infections knownto affect the different parts of the urinary tract accounting for major antibacterial drug consumption. About 150million UTI cases were diagnosed every year. Urinary tract infections are the most important and most commonsite of infections in a diabetic patient. Diabetic patients have been found to have a 5-fold frequency of acutepyelonephritis at autopsy than non-diabetics. Most of the urinary tract infections in patients with diabetes arerelatively asymptomatic. The presence of this syndrome predisposes to much more severe infections,particularly in patients with acute ketoacidosis, poor diabetic control, diabetic complications such as neuropathy,vasculopathy, and nephropathy. The Gram-negative aerobic bacilli are the large group of bacterial pathogensthat cause UTI with few species of Gram-positive bacteria. However, some fungi, parasites, and viruses havealso been reported to invade the urinary tract. Urinary tract infection affects women more than men due toseveral factors such as proximity of the genital tract to the urethra, anatomy of the female urethra, sexualactivity, menopause, and pregnancy. Other possible risk factors of UTI include allergy, obesity, diabetes, pasthistory of UTI, contraceptive use, catheter use, and family history.
Read ArticleHEAT DISSIPATION AT CEMENT HARDENING
During the construction of concrete structures of small cross-sections, the release of heat during cementhardening has no harmful effects. With the increasing temperature of the hardening cement mass, the rate ofcement hydration increases. This increases the rate of release of its heat of hydration of cement. Theconsequence of the accelerated process of hydration of the binder is a more intensive increase in the strengthof cement stone than in the case of hardening under normal conditions. This fact is widely used in practice forthe intensification of the hardening of concrete. When structures with small cross-sections are being built, theheat released during hardening is relatively quickly transferred to the surrounding space and does not cause asignificant increase in temperature. In structures made of massive concrete (with a large cross-section), thisheat is stored in the interior of the array for a long time, which causes a rather large rise in temperature and itsslow drop. This is due to the fact that heat transfer to the external environment is hampered here by theconsiderable thickness of the massif and the rapid rate of concreting, mechanized laying of large masses ofconcrete. As a result, a temperature difference is created between the internal and external parts of thestructure and harmful internal stresses arise that can cause cracking in the hardened concrete. This leads to aviolation of its solidity. The faster cement hydrates, the sooner and more heat is released. The types of cementswith a high content of tricalcium silicate and aluminate emit more heat and rather than types of cement with ahigh content of dicalcium silicate and tetra-calcium aluminoferrite. However, the latter has a lower strength. Theincrease in strength resulting from the hydration process is inevitably associated with the release of heat into theenvironment. C
Read Article