SOUTHERN JOURNAL OF SCIENCES

It is investigated the effect of synthesized organic compounds of 6-hydroxy-2,2,4-trimethyl-1,2- dihydroquinoline, its derivatives, and hydrogenated analogs. These compounds affected the height of seedlings when they were used for pre-sowing seed treatment of the following ornamental plants: annual ornamental grass – scarlet sage (Salvia splendens) and woody plant – yellow rhododendron (Rhododendron luteum). Prior to the sprouting process, the seeds of Rh. luteum and S. splendens were soaked in water solutions of compounds with concentrations of 0.01%, 0.05%, and 0.1% for 18 hours. Dihydro- and tetrahydroquinolines with a concentration of 0.05% proved to be the most effective for both plants. For Rhododendron luteum, the compounds of 6-hydroxy-2,2,4-trimethyl-1,2-dihydroquinoline, its derivatives, and hydrogenated analogs with a concentration of 0.1% proved to be the most effective. Dihydroquinolines at concentrations of 0.05 and 0.1% proved to have the strongest effect when applied to the studied perennial woody plant (Rhododendron luteum). Dihydroquinoline at the concentration of 0.05% also proved to be effective when applied to the annual grass (Salvia splendens). For annual S. splendens, tetrahydroquinoline at concentrations of 0.01 and 0.05% appeared to be the most effective. The pre-sowing seed treatment of grass Salvia splendens and woody plant Rhododendron luteum with the studied compounds demonstrated that their effect on the height of the seedlings is species-specific. The pre-sowing seed treatment of Rh. luteum and S. splendens allows increasing the height of the seedlings by 3-61 % and 17-25 %, respectively. It is suggested using the compounds of 6-hydroxy-2,2,4- trimethyl-1,2-dihydroquinoline, its derivatives, and hydrogenated analogs as effective growth stimulators for ornamental grasses and woody plants.

Background: Despite innovations in orthopedic dentistry, the manufacture of removable dentures belongs to the most popular orthopedic care category. Removable dentures are combined stimuli that affect the mucous membrane and neuro-receptor apparatus. Acrylic plastic prostheses, widely used in prosthetic dentistry, have a negative side mechanical, chemical-toxic, sensitizing, and thermal insulating effect on oral tissue and prosthetic impression area. This is often complicated by a violation of the biocenosis of the oral cavity, the growth of pathogenic microflora that releases toxins, especially an increase in the number of yeast colonies that irritate the oral mucosa and prosthetic stomatitis. According to the WHO, one-fifth of the world s population suffers or has suffered various candidiasis forms at least once. The worldwide increase in the incidence of the disease is primarily related to the fact that this infection is opportunistic, more than half of the world s population is a carrier of fungi of this kind, i.e., in most cases, it is an endogenous infection, which makes candidiasis different from other opportunistic mycoses. Aims: The purpose of this study was to study the prevalence of candidiasis in patients using removable dentures and to evaluate the effectiveness and prevention of candidiasis treatment. Methods: 100 patients with oral candidiasis of various age groups from 45 to 65 years were observed. Of these, 60 patients with removable plate prostheses; 40 patients with partially removable prostheses. Results and Discussion: Chronic forms of candidiasis were diagnosed in 40 patients and with exacerbation of chronic forms of candidiasis-60 people. The number of untreated carious cavities and poor hygienic condition of the oral cavity directly affects the severity of candidiasis. Acute forms of candidiasis were observed mainly in patients with high DMF and PMA indices. The severity of candidiasis depends on the degree and duration of wearing dentures and hygienic conditions - the most severe forms of invasive candidiasis were observed in the presence of removable plate prostheses, the complete absence of teeth, and the use of a prosthesis for more than 10-15 years. A combined lesion of the oral mucosa and the red border of the lips was observed mainly in patients older than 60 years. Conclusions: The presence of candidiasis in the oral cavity in patients with removable plate prostheses leads to a statistically significant change in the indicators of local immunity of the oral cavity: an increase in the concentration of serum IgG and IgA and the values of the coefficient of the balance of local immunity factors.

Background: Medical institutions collect a vast amount of sensitive patient data for personalized treatments and health trend analysis. However, this raises concerns regarding the privacy of patient data, as it contains sensitive and confidential information. Aims: Develop an anonymization tool using diverse techniques to protect data while preserving its utility. Methods: A Python-based data anonymization tool for medical datasets supporting both categorical and numerical data is developed. It employs various methods, including data perturbation, binning, scaling, transformation, and differential privacy. Results: The tool was able to anonymize sensitive data, both categorical and numerical, while preserving its utility for further analysis. Discussion: The Privacy-Preserving Data Anonymization Tool advances sensitive medical data management by anonymizing both categorical and numerical data using various techniques while retaining data utility. Conclusions: The Anonymization Tool addresses patient data privacy concerns by balancing data utility with privacy, enabling secure medical data use in research.