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INQUIRY FOR SUITABLE LOCATIONS FOR A DRILLING REGIME AT AN UPSLOPE ROCKY KNOLL OF LAWU ESTATE, WESTERN BYPASS, MINNA, NIGERIA

Background: A client requested that the study group help determine locations that would be suitable for a drilling regime at his lot, located at an upslope rocky knoll of Lawu Estate, Minna, Nigeria. Aim: The aim of this study is to carry out a purpose-specific survey to pinpoint the best locations in a built-up property at the upmarket Lawu Estate that would be suitable for a drilling regime targeted for household consumption. Methods: The study area was reconnoitered by the survey crew in order to georeference the locations that would be occupied for the vertical electrical sounding survey in the 30 m x 20 m lot. Owing to the extensive build-up at this lot, only a four-point traverse along the 30-metric dimension traverse of the frontage of the building was demarcated in the northeasterly direction, thereby limiting the desire of the survey crew to define an appropriate survey grid. The data-acquisition pattern at the 4 x 1 survey stations of the frontage-traverse of the lot followed the “traditional” sequence of Schlumberger array layout measurements, whence the survey crew progressed with current-electrode spacing either end of a survey point located at this frontage-traverse targeting a maximum survey depth of 100 m. Result: The acquired vertical electrical-sounding data set for this study was recorded on purpose-specific data sheets. Discussion: Based on empirical rules-of-thumb procedures for interpreting vertical electrical sounding data at the Nigerian Basement Complex geological province, “assured” groundwater location and “strongly aquiferous” location, deductive inferences were drawn with regards to only vertical electrical sounding Station 4. Conclusion: Thus, it is recommended that VES Station 4 be exploited in the planned drilling program of the client, especially since this survey point checks off 100 percent of the constraints imposed by the rules-of-thumb interpretation procedures.
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DETECTION OF EPSTEIN-BARR VIRUS (EBV) IN WOMEN WITH BREAST CANCER IN IRAQ USING IN-SITU HYBRIDIZATION AND IMMUNOHISTOCHEMICAL TECHNIQUES

Background: The Epstein-Barr virus (EBV) has recently been identified in human breast cancer globally, potentially contributing to the initiation and progression of this malignancy, as well as gastric cancer, nasopharyngeal carcinoma, and bladder cancer. It has been newly associated with breast cancer. Globally, breast cancer affects more women than any other type of cancer. In Iraq, the prevalence of breast cancer is comparable. Aims: The study examined Iraqi women diagnosed with invasive ductal carcinoma (IDC) and invasive lobular carcinoma (ILC) to detect Epstein-Barr Virus Nuclear Antigen-1 (EBNA-1) and encoded RNA (EBER). Methods: A total of 50 formalin-fixed paraffin-embedded tissues from invasive ductal carcinoma (IDC) (92%) and invasive lobular carcinoma (ILC) (8%) biopsy samples constituted the case group, while 30 formalin-fixed paraffin-embedded tissues from non-cancerous breast tissue served as the control group. The presence of Epstein-Barr virus protein (EBER) in breast tissue was assessed using immunohistochemistry (IHC) and chromogenic in situ hybridization (CISH) methods. Results: EBER RNA signals were found in 31 (62%). EBER RNA signals were seen in 3 (10%) control group participants. Significant differences (P<0.04) were seen in EBV EBER RNA positive signals among study groups. Immunohistochemistry showed nuclear brown staining in 34 (68%) breast cancer patients. Control group: 3 (10%). Discussion: The research identified a statistically significant correlation between EBV positivity and breast cancer among Iraqi women, especially concerning invasive ductal carcinoma. The results corroborate previous reports of elevated EBV levels in malignant breast tissues relative to controls. Although detection approaches such as CISH and IHC provide complementary insights, additional studies are needed. Conclusions: The study concludes that EBNA-1 and EBV EBER RNA were overexpressed in our population group.
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TREATMENTS FOR ACUTE LYMPHOBLASTIC LEUKEMIA: A COMPARISON BETWEEN TISAGENLECLEUCEL AND CLOFARABINE

Background: Acute lymphoblastic leukemia (ALL) is a heterogeneous hematological malignancy predominantly affecting individuals under 20 years of age. Traditional chemotherapy, such as clofarabine, has shown efficacy; however, novel immunotherapeutic strategies like tisagenlecleucel (Kymriah®) have significantly altered the treatment paradigm. Aim: This study aimed to perform a comparative analysis of tisagenlecleucel, a CAR-T cell therapy, and clofarabine, a second-generation purine nucleoside analog, evaluating their mechanisms of action, therapeutic benefits, limitations, and clinical applicability across diverse patient populations. Methods: A systematic comparative evaluation was conducted, encompassing pharmacological characteristics, mechanisms of action, treatment protocols, efficacy, safety profiles, and clinical indications of both agents. The analysis considered pharmacokinetic and pharmacodynamic data and included patient demographic variables. Results: Tisagenlecleucel demonstrated high efficacy in refractory B-cell ALL, with durable responses and a blood half-life of 128 days, but with notable immune-related adverse effects such as cytokine release syndrome. Clofarabine, effective across a broader patient population, acts via multiple antitumor mechanisms but carries significant toxicity risks, including infection and sepsis. Discussion: The therapies present distinct clinical profiles: tisagenlecleucel offers targeted immunotherapy with high specificity but requires specialized infrastructure and management of immune toxicities. Clofarabine is more widely accessible and applicable, but is associated with conventional chemotherapy-related side effects. Treatment accessibility and cost differ markedly between the two. Conclusions: Therapy selection should be personalized based on patient-specific factors and institutional resources. Tisagenlecleucel is ideal for pediatric and young adult patients with relapsed/refractory B-cell ALL in CAR-T-capable centers, while clofarabine remains a viable option for broader ALL populations, particularly when genetic therapies are not feasible. Further research is needed to optimize therapeutic strategies and improve access to advanced treatments.
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General information

SOUTHERN JOURNAL OF SCIENCES

    General information about this journal
  • Title: SOUTHERN JOURNAL OF SCIENCES
  • Short Title: South. J. Sci.
  • ISSN: 2764-5959 (Online); ISSN: 2764-5967 (Print)
  • Universal Decimal Classification (UDC): 001
  • Review Process: Double-Blind Peer-Review
  • Accessibility: Platinum Open Access, NO-APCs.
  • Digital preservation: Portico
  • Frequency of Publication: biannual [2 issues per year]. Journal publication schedule
  • DOI: 10.48141/2764-5959
  • Website: https://www.sjofsciences.com/
  • Country: BRAZIL
  • Publisher: Araucária - Scientific Association.
  • Language of Publication: ENGLISH / PORTUGUESE*
  • *Year that the Journal started accepting manuscripts in Portuguese: 2020
  • First issue year: 1993
  • Free full text: Yes
  • Indexed in: Index Copernicus; Latindex, and I2OR.
  • Formerly known as the Southern Brazilian Journal of Chemistry (1993 to 2021).
  • Former ISSN: 2674-6891 (Online); Former ISSN: 0104-5431 (Print).
  • Website last update: 06/07/2025.

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REVIEW AND STUDY OF METAL COMPLEXES WITH ANTIFUNGAL POTENTIAL AGAINST Candida albicans STRAINS

Background: Candidiasis, caused mainly by Candida albicans yeast, is a pathology that affects a significant amount of people in the world, mainly women, thus being a public health issue. In addition, clinical practice has found it difficult to treat candidiasis for two reasons: the multidrug resistance associated with the exacerbated use of available drugs and the high number of side effects caused by current antifungal drugs. In this scenario, this work is a literature review on the antifungal activity of metal complexes against C. albicans since they are extensively studied for their varied applications in health sciences, as an object of study in the area of inorganic chemistry, in the subareas of bioinorganic chemistry and pharmaceutical chemistry. Aim: The present work consists of a literature review in electronic databases on the potential antifungal action against Candida albicans presented by metal complexes. Methods: Data was collected using the Capes, PubMed, Cochrane Reviews and Virtual Health Library (BVS) databases. Results: The results obtained through bibliographic surveys show the importance of studies of metal complexes against the strain of C. albicans, which have promising inhibitory activities and in some cases, with Minimum Inhibitory Concentration (MIC) values lower than 20µg/mL Discussion: The results obtained through bibliographic surveys show the importance of studies of metal complexes against the strain of C. albicans, which have promising inhibitory activities, and in some cases, with Minimum Inhibitory Concentration (MIC) values lower than 20µg/mL. Conclusion: Highlighting the activity performed by ruthenium complexes and Schiff bases when coordinated to metallic ions arouses great interest in a future study of a complex of this metal with a Schiff base in its coordination site.
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USING SYNTHESISED ORGANIC COMPOUNDS AS ENVIRONMENTALLY FRIENDLY RETARDANTS FOR ORNAMENTAL PLANTS

The pre-sowing treatment of scarlet sage (Salvia splendens Ker Gawl.) seeds with 4-methyl-2-piperidin1-yl-pyrimidine-5-carboxylic acid at concentrations of 0.01, 0.05, and 0.1% proved to have an obvious inhibiting effect. Prior to sowing, the seeds of Salvia splendens were soaked in a water suspension of 4-methyl-2-piperidin-1-yl-pyrimidine-5-carboxylic acid and 4-methyl-2-morpholin-4-pyrimidine-5-carboxylic acid with concentrations of 0.01%, 0.05%, and 0.1% for 18 hours. On the 42nd day of the experiment, the seedlings, having been preliminarily hardened for 12 days, were removed from the greenhouse and planted on the field. The pre-sowing treatment of Salvia splendens seeds with 4-methyl-2-morpholin-4-pyrimidine-5-carboxylic acid proved to have the inhibiting effect at concentrations of 0.01 and 0.05%. The height of the seedlings decreased by 13.3-43.7%. It was revealed that 4-methyl-2-piperidin-1-yl-pyrimidine-5-carboxylic acid at concentrations of 0.01, 0.05, and 0.1% decreased the growth of the seedlings by 30.4-43.7%, and 4-methyl-2-morpholin-4-pyrimidine-5-carboxylic acid at concentrations of 0.01 and 0.05% decreased the growth of the seedlings by13.3-22.2%. By contrast, the effect of pyrimidinecarboxylic acids on seed germination and plant height of another annual flower – spreading marigold (Tagetes patula L.) was stimulating. It was investigated some different concentrations from 0.01 to 0.05 %. The same concentrations of identical compounds were tested, but effects from them were opposite for Tagetes patula, and Salvia splendens seedlings. Сonsequently, the species-specific effect of pyrimidinecarboxylic acids on seed germination and plant height for ornamental grasses takes place. Therefore,4-methyl-2-piperidin-1-yl-pyrimidine-5-carboxylic acid and 4-methyl-2-morpholin4-pyrimidine-5-carboxylic acid are recommended as growth retardants for Salvia splendens. 
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INTERACTIVE 3D RECONSTRUCTION AND DLT CAMERA CALIBRATION: A MANUAL REGISTRATION APPROACH

Background: This paper presents a straightforward and intuitive method for interactive 3D reconstruction and Direct Linear Transformation (DLT) camera calibration using a single image of a structured scene with known object dimensions. The method relies on manual registration of pairs of points on both the image and the terrain, allowing for precise alignment and calibration. Aim: By utilizing this method, users can easily reconstruct 3D scenes and calibrate cameras without the need for complex algorithms or extensive computational resources. Our approach offers a user-friendly solution for 3D reconstruction and camera calibration, making it accessible to a wider audience and applicable in a range of fields such as computer vision, augmented reality, and virtual reality. Methods: This work primarily focuses on the determination of the projection matrix, which plays a crucial role in mapping 3D points onto a 2D image plane. The projection matrix encapsulates both the intrinsic parameters of the camera (such as focal length and optical center) and the extrinsic parameters (such as camera position and orientation in the world coordinate system). By accurately determining the projection matrix, we can effectively project 3D points onto the 2D image plane, enabling tasks like 3D reconstruction, camera localization, and augmented reality applications. Results: We present experimental results obtained from testing the method on an image of a known object, demonstrating its effectiveness and accuracy in producing realistic 3D reconstructions. Discussion: The method's reliance on manual registration of point pairs allows for precise alignment and calibration without the need for complex algorithms or extensive computational resources. This user-friendly approach makes 3D reconstruction and camera calibration accessible to a wider audience and applicable in various fields. Conclusions: Overall, our approach offers a practical and accessible solution for 3D reconstruction and camera calibration, expanding the potential applications in computer vision, augmented reality, and virtual reality.
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SOUTHERN JOURNAL OF SCIENCES

The SOUTHERN JOURNAL OF SCIENCES publishes articles in Chemistry, Physics, Mathematics, Biology, Pharmacy, Medicine, Engineering, Industrial Science, Agriculture, and related interdisciplinary areas and is intended to fill a gap in terms of scientific information worldwide. All manuscripts can be published either in English or Portuguese, with tile, abstracts, and keywords in English. At present, there are NO PUBLICATION FEES. Editors will cover web hosting, open access, DOI number, and other service costs.

We have set high standards for the articles to be published by ensuring strong but fair refereeing by at least two reviewers. We hope that this Journal will provide a forum for disseminating high-quality research in chemistry and related areas and are open to any questions and suggestions. Starting in 2020, the SOUTHERN JOURNAL OF SCIENCES will have two issues per year (June and December).

Thank you very much for choosing the SOUTHERN JOURNAL OF SCIENCES to publish your paper!
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