Latest Edition Highlights (Issue 41)

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DIET, SUPPLEMENTATION, PERFORMANCE, AND SUBJECTIVE EXPERIENCE IN MARATHON RUNNERS

Background: Nutrition strategies may influence marathon performance and runners’ subjective experience. Aims: To evaluate the association between dietary habits, supplement use, performance, and subjective experience in runners of the 2025 Mendoza International Marathon. Methods: A survey of 240 runners from the 2025 Mendoza International Marathon examined dietary habits, supplement use, performance, and subjective experience. Results: Nutritional counseling was linked to more favorable perceptions. Conversely, pre-race alcohol and excessive carbohydrates with poor hydration increased gastrointestinal complaints. Supplements showed no measurable performance or well-being benefits. Discussions: These findings suggest that pre-race nutritional behaviors may have a greater influence on runners’ subjective experience than supplement use.Conclusions: Nutritional guidance may improve race experience, whereas poor pre-race practices increase gastrointestinal complaints.
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CARDIOVASCULAR RISK AND DIETARY HABITS IN TRANSGENDER ADULTS RECEIVING HORMONE THERAPY

Background: Transgender and gender-diverse individuals experience health inequities that may increase cardiometabolic risk. Gender-affirming hormone therapy has been associated with changes in body composition, lipid metabolism, and cardiovascular risk markers. However, limited evidence is available regarding dietary habits and cardiovascular risk profiles in transgender populations in Latin America. Objective: To evaluate cardiovascular risk factors and cardioprotective food consumption among transgender adults receiving gender-affirming hormone therapy. Methods: A quantitative, observational, descriptive, and cross-sectional study was conducted in transgender adults undergoing gender-affirming hormone therapy in Mendoza, Argentina. Eighty-seven participants completed surveys regarding sociodemographic characteristics, lifestyle habits, nutritional counseling, and consumption of cardioprotective foods. We assessed anthropometric indicators and biochemical parameters related to cardiovascular risk. Statistical analyses were performed using GraphPad Prism 8. Data were analyzed using Spearman correlation, the chi-square test, and the Mann-Whitney U test. Results: A high prevalence of modifiable cardiovascular risk factors was identified, including overweight, sedentary behavior, smoking, and low intake of cardioprotective foods. More than half of the participants had never received nutritional counseling. No statistically significant differences were observed between transgender women and transgender men in the evaluated anthropometric and biochemical variables. Nevertheless, significant correlations were identified between body mass index, waist circumference, waist-to-height ratio, and atherogenic lipid markers. Dietary quality showed limited associations with cardiovascular risk indicators, although higher dietary quality was positively associated with HDL cholesterol levels in transgender men. Conclusion: The study highlights the presence of multiple cardiovascular risk factors in transgender individuals receiving gender-affirming hormone therapy and emphasizes the importance of integrating nutritional assessment and cardiometabolic monitoring into comprehensive transgender healthcare. These findings support the need for inclusive nutritional interventions and longitudinal studies addressing cardiovascular health in transgender populations.
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SEVENTY YEARS OF THE BRAZILIAN FEDERAL COUNCIL OF CHEMISTRY (1956–2026): INSTITUTIONAL TRAJECTORY, PRESIDENCIES, AND PERSPECTIVES FOR THE CHEMISTRY PROFESSION - EN

Background: In 2026, the CFQ/CRQ System turns 70 (Law No. 2,800/1956), overseeing a sector responsible for ~11% of industrial GDP, but it lacked a chronological reconstruction based on its own official primary records. Aim: To reconstruct the System's legal genesis, establish a documented official chronology of its presidencies, and discuss current regulatory challenges. Methods: Historiographical-descriptive documentary research based on normative sources and unprecedented access to the internal record "Galeria de Presidentes," provided by the CFQ Presidency Office in 2026. Results: Eight substantive presidencies and interim periods (1957–2026) were detailed, substantiating the interim exercise by Oscar Bergstron Lourenço (1963–1964) and Juvenal Dória's inauguration in 1964. The System now comprises 21 regional councils and over 230,000 registrants. The study identified under-documentation of Hebe Martelli's trajectory (the only female president) and an open divergence regarding the number of regional councils created in 1957. Discussion: Normative Resolution No. 36/1974 remains the milestone for professional attributions. Recent regulations revisit historical challenges, such as attributing competencies to hybrid curricula and establishing chemical safety as a public good, requiring anticipation of energy, materials, and digital transitions. Limitations: The chronology relies on institutional records that the authors did not independently audit against primary archives. Conclusions: Access to primary records consolidated the documentary memory of the System's seventy years, whose legacy lies in adapting the regulatory framework to technological transformations.
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General information

SOUTHERN JOURNAL OF SCIENCES

    General information about this journal
  • Title: SOUTHERN JOURNAL OF SCIENCES
  • Short Title: South. J. Sci.
  • ISSN: 2764-5959 (Online); ISSN: 2764-5967 (Print)
  • Universal Decimal Classification (UDC): 001
  • Review Process: Double-Blind Peer-Review
  • Accessibility: Platinum Open Access, NO-APCs.
  • Digital preservation: Portico
  • Frequency of Publication: biannual [2 issues per year]. Journal publication schedule
  • DOI: 10.48141/2764-5959
  • Website: https://www.sjofsciences.com/
  • Country: BRAZIL
  • Publisher: Mendoza University - Argentina | Araucária - Scientific Association (leaving).
  • Language of Publication: ENGLISH / PORTUGUESE* / SPANISH**
  • *Year the Journal started accepting manuscripts in Portuguese: 2020
  • *Year the Journal started accepting manuscripts in Spanish: 2026
  • First issue year: 1993
  • Free full text: Yes
  • Indexed in: Index Copernicus; Latindex, and I2OR.
  • Formerly known as the Southern Brazilian Journal of Chemistry (1993 to 2021).
  • Former ISSN: 2674-6891 (Online); Former ISSN: 0104-5431 (Print).
  • Website last update: 18/09/2026.

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FROM AIR FORCE TO HYPERSONIC FUTURE: ÉLCIO GERÔNIMO DE OLIVEIRA'S JOURNEY IN BRAZILIAN AEROSPACE DEVELOPMENT (ENGLISH VERSION)

Introdução: A entrevista com Élcio Gerônimo de Oliveira, conduzida pelo repórter Luis, apresenta a trajetória profissional de um pesquisador brasileiro com experiência na Força Aérea Brasileira e no meio acadêmico, com foco em sistemas espaciais e veículos hipersônicos. Objetivos: Documentar a carreira e contribuições de Élcio para o desenvolvimento aeroespacial brasileiro, destacando sua transição da carreira militar para a acadêmica e sua participação em projetos estratégicos, especialmente o projeto 14X. Métodos: A entrevista foi estruturada em blocos temáticos, abordando a carreira militar, a experiência acadêmica e, com maior detalhamento, o envolvimento no projeto do veículo hipersônico 14X. Foram realizadas perguntas abertas, permitindo ao entrevistado compartilhar sua experiência e conhecimento técnico. Resultados: Élcio descreveu sua progressão na Força Aérea Brasileira, desde pesquisador até vice-chefe da Diretoria de Espaço, destacando o desenvolvimento de veículos lançadores, sistemas de navegação inercial e o projeto SARA. Relatou sua transição para a carreira acadêmica, incluindo sua experiência como professor na Universidade de Luleå, na Suécia. Élcio detalhou sua coordenação no projeto 14X, um veículo hipersônico que alcançou Mach 7, com perspectivas de atingir Mach 10. Discussão: A entrevista revela a importância da cooperação internacional e da transferência de tecnologia, exemplificada pela doação do primeiro laboratório de hipersônica do Brasil. Evidencia também os desafios técnicos na construção de veículos hipersônicos e o potencial dessas tecnologias para aplicações militares e civis. Conclusão: A carreira de Élcio Gerônimo de Oliveira exemplifica a contribuição brasileira para pesquisa aeroespacial avançada, demonstrando a capacidade nacional de desenvolver tecnologias estratégicas como veículos hipersônicos, apesar das limitações de recursos, e apontando possibilidades futuras para o transporte e exploração espacial.
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TREATMENTS FOR ACUTE LYMPHOBLASTIC LEUKEMIA: A COMPARISON BETWEEN TISAGENLECLEUCEL AND CLOFARABINE

Background: Acute lymphoblastic leukemia (ALL) is a heterogeneous hematological malignancy predominantly affecting individuals under 20 years of age. Traditional chemotherapy, such as clofarabine, has shown efficacy; however, novel immunotherapeutic strategies like tisagenlecleucel (Kymriah®) have significantly altered the treatment paradigm. Aim: This study aimed to perform a comparative analysis of tisagenlecleucel, a CAR-T cell therapy, and clofarabine, a second-generation purine nucleoside analog, evaluating their mechanisms of action, therapeutic benefits, limitations, and clinical applicability across diverse patient populations. Methods: A systematic comparative evaluation was conducted, encompassing pharmacological characteristics, mechanisms of action, treatment protocols, efficacy, safety profiles, and clinical indications of both agents. The analysis considered pharmacokinetic and pharmacodynamic data and included patient demographic variables. Results: Tisagenlecleucel demonstrated high efficacy in refractory B-cell ALL, with durable responses and a blood half-life of 128 days, but with notable immune-related adverse effects such as cytokine release syndrome. Clofarabine, effective across a broader patient population, acts via multiple antitumor mechanisms but carries significant toxicity risks, including infection and sepsis. Discussion: The therapies present distinct clinical profiles: tisagenlecleucel offers targeted immunotherapy with high specificity but requires specialized infrastructure and management of immune toxicities. Clofarabine is more widely accessible and applicable, but is associated with conventional chemotherapy-related side effects. Treatment accessibility and cost differ markedly between the two. Conclusions: Therapy selection should be personalized based on patient-specific factors and institutional resources. Tisagenlecleucel is ideal for pediatric and young adult patients with relapsed/refractory B-cell ALL in CAR-T-capable centers, while clofarabine remains a viable option for broader ALL populations, particularly when genetic therapies are not feasible. Further research is needed to optimize therapeutic strategies and improve access to advanced treatments.
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STATISTICAL VALIDATION OF TRIPLE COLOCALIZATION ANALYSIS

Background: in the last decades, colocalization analysis of fluorescently tagged biomolecules has proven to be a powerful approach to studying functional relationships between these biomolecules. However, in many cases, to give this analysis a biological meaning, colocalization coefficients must be tested statistically, comparing them with the colocalization expected by chance. Aim: It addressed the statistical significance of triple colocalization to distinguish real triple colocalization and classify different triple signal scenarios. Methods: we use biological and generated images of triple signal scenarios to contrast seven independent statistical facts with independent statistical tests. Three of these tests correspond to pairwise relationships (double scrambling tests), and the others correspond to triple relationships: single scrambling tests (red, green, and blue scrambling) and the triple scrambling test. The analysis and methodology proposed can be reproduced using the application developed in our laboratory. Results: In the study approach, we found true triple relationships ignored by using traditional methods of computing the statistical significance, while we could reinterpret cases of not significant triple colocalization wrongly considered as significant by traditional methods. Discussion: single scrambling tests can reveal significant triple colocalization for low levels of triple co-occurrence, even when all pairwise relationships were exclusion relationships. Moreover, on the other hand, single scrambling tests can reveal the absence of a significant triple colocalization for high levels of triple co-occurrence, even when all pairwise relationships were significant colocalization. Conclusion: all scrambling tests are useful to classify a specific scenario of a triple relationship. Dynamics like mitosis can be distinguished into their phases by triple signal relationships using these 7 independent statistical tests.
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SOUTHERN JOURNAL OF SCIENCES

The SOUTHERN JOURNAL OF SCIENCES publishes articles in Chemistry, Physics, Mathematics, Biology, Pharmacy, Medicine, Engineering, Industrial Science, Agriculture, and related interdisciplinary areas and is intended to fill a gap in terms of scientific information worldwide. All manuscripts can be published either in English or Portuguese, with tile, abstracts, and keywords in English. At present, there are NO PUBLICATION FEES. Editors will cover web hosting, open access, DOI number, and other service costs.

We have set high standards for the articles to be published by ensuring strong but fair refereeing by at least two reviewers. We hope that this Journal will provide a forum for disseminating high-quality research in chemistry and related areas and are open to any questions and suggestions. Starting in 2020, the SOUTHERN JOURNAL OF SCIENCES will have two issues per year (June and December).

Thank you very much for choosing the SOUTHERN JOURNAL OF SCIENCES to publish your paper!
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