Latest Edition Highlights (Issue 39)

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TREATMENTS FOR ACUTE LYMPHOBLASTIC LEUKEMIA: A COMPARISON BETWEEN TISAGENLECLEUCEL AND CLOFARABINE

Background: Acute lymphoblastic leukemia (ALL) is a heterogeneous hematological malignancy predominantly affecting individuals under 20 years of age. Traditional chemotherapy, such as clofarabine, has shown efficacy; however, novel immunotherapeutic strategies like tisagenlecleucel (Kymriah®) have significantly altered the treatment paradigm. Aim: This study aimed to perform a comparative analysis of tisagenlecleucel, a CAR-T cell therapy, and clofarabine, a second-generation purine nucleoside analog, evaluating their mechanisms of action, therapeutic benefits, limitations, and clinical applicability across diverse patient populations. Methods: A systematic comparative evaluation was conducted, encompassing pharmacological characteristics, mechanisms of action, treatment protocols, efficacy, safety profiles, and clinical indications of both agents. The analysis considered pharmacokinetic and pharmacodynamic data and included patient demographic variables. Results: Tisagenlecleucel demonstrated high efficacy in refractory B-cell ALL, with durable responses and a blood half-life of 128 days, but with notable immune-related adverse effects such as cytokine release syndrome. Clofarabine, effective across a broader patient population, acts via multiple antitumor mechanisms but carries significant toxicity risks, including infection and sepsis. Discussion: The therapies present distinct clinical profiles: tisagenlecleucel offers targeted immunotherapy with high specificity but requires specialized infrastructure and management of immune toxicities. Clofarabine is more widely accessible and applicable, but is associated with conventional chemotherapy-related side effects. Treatment accessibility and cost differ markedly between the two. Conclusions: Therapy selection should be personalized based on patient-specific factors and institutional resources. Tisagenlecleucel is ideal for pediatric and young adult patients with relapsed/refractory B-cell ALL in CAR-T-capable centers, while clofarabine remains a viable option for broader ALL populations, particularly when genetic therapies are not feasible. Further research is needed to optimize therapeutic strategies and improve access to advanced treatments.
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FROM AIR FORCE TO HYPERSONIC FUTURE: ÉLCIO GERÔNIMO DE OLIVEIRA'S JOURNEY IN BRAZILIAN AEROSPACE DEVELOPMENT (ENGLISH VERSION)

Introdução: A entrevista com Élcio Gerônimo de Oliveira, conduzida pelo repórter Luis, apresenta a trajetória profissional de um pesquisador brasileiro com experiência na Força Aérea Brasileira e no meio acadêmico, com foco em sistemas espaciais e veículos hipersônicos. Objetivos: Documentar a carreira e contribuições de Élcio para o desenvolvimento aeroespacial brasileiro, destacando sua transição da carreira militar para a acadêmica e sua participação em projetos estratégicos, especialmente o projeto 14X. Métodos: A entrevista foi estruturada em blocos temáticos, abordando a carreira militar, a experiência acadêmica e, com maior detalhamento, o envolvimento no projeto do veículo hipersônico 14X. Foram realizadas perguntas abertas, permitindo ao entrevistado compartilhar sua experiência e conhecimento técnico. Resultados: Élcio descreveu sua progressão na Força Aérea Brasileira, desde pesquisador até vice-chefe da Diretoria de Espaço, destacando o desenvolvimento de veículos lançadores, sistemas de navegação inercial e o projeto SARA. Relatou sua transição para a carreira acadêmica, incluindo sua experiência como professor na Universidade de Luleå, na Suécia. Élcio detalhou sua coordenação no projeto 14X, um veículo hipersônico que alcançou Mach 7, com perspectivas de atingir Mach 10. Discussão: A entrevista revela a importância da cooperação internacional e da transferência de tecnologia, exemplificada pela doação do primeiro laboratório de hipersônica do Brasil. Evidencia também os desafios técnicos na construção de veículos hipersônicos e o potencial dessas tecnologias para aplicações militares e civis. Conclusão: A carreira de Élcio Gerônimo de Oliveira exemplifica a contribuição brasileira para pesquisa aeroespacial avançada, demonstrando a capacidade nacional de desenvolver tecnologias estratégicas como veículos hipersônicos, apesar das limitações de recursos, e apontando possibilidades futuras para o transporte e exploração espacial.
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INTERVIEW WITH DEPUTY VICE CHANCELLOR DR. O. A. OMOTESHO, UNIVERSITY OF ILORIN, NIGERIA (ENGLISH VERSION)

Background: The University of Ilorin, founded in 1975 in Nigeria, has evolved from 3 to 16 faculties, becoming the country's most sought-after institution for the past two decades. Aims: To document the institutional evolution, identify the most demanded programs, assess scientific output, examine internationalization strategies, and understand strategic development objectives. Methods: Structured interview with Vice-Chancellor Dr. Olubumi Abayomi Omotesho, following a standardized protocol covering historical, academic, scientific, and strategic aspects of the institution, under Creative Commons license format. Results: The university expanded to 16 faculties in 49 years. The most demanded programs are Medicine and Nursing, followed by Pharmacy, Law, Engineering, and Accounting. Areas with the highest scientific output: Medicine, Biological/Agricultural Sciences, and Engineering. It offers 340 postgraduate programs with approximately 7,523 students. There is a dedicated infrastructure for internationalization, with plans for international accommodations. Discussion: The predominance of healthcare courses reflects global employability trends. Research aligned with Sustainable Development Goals demonstrates a contemporary vision. The institutional goal (number one in Nigeria, top 10 in Africa, top 500 globally) shows a measurable strategic approach. Commitment to internationalization aligns with global education trends. Conclusions: The institution exemplifies an evolving African university focused on academic excellence, scientific relevance, and internationalization. The prioritization of student-centered development, clear positioning goals, and international collaboration initiatives establish solid foundations for its contribution to regional and global knowledge.
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General information

SOUTHERN JOURNAL OF SCIENCES

    General information about this journal
  • Title: SOUTHERN JOURNAL OF SCIENCES
  • Short Title: South. J. Sci.
  • ISSN: 2764-5959 (Online); ISSN: 2764-5967 (Print)
  • Universal Decimal Classification (UDC): 001
  • Review Process: Double-Blind Peer-Review
  • Accessibility: Platinum Open Access, NO-APCs.
  • Digital preservation: Portico
  • Frequency of Publication: biannual [2 issues per year]. Journal publication schedule
  • DOI: 10.48141/2764-5959
  • Website: https://www.sjofsciences.com/
  • Country: BRAZIL
  • Publisher: Araucária - Scientific Association.
  • Language of Publication: ENGLISH / PORTUGUESE*
  • *Year that the Journal started accepting manuscripts in Portuguese: 2020
  • First issue year: 1993
  • Free full text: Yes
  • Indexed in: Index Copernicus; Latindex, and I2OR.
  • Formerly known as the Southern Brazilian Journal of Chemistry (1993 to 2021).
  • Former ISSN: 2674-6891 (Online); Former ISSN: 0104-5431 (Print).
  • Website last update: 06/07/2025.

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MODELING OF THE NITROGEN PARAMETER OF THE PARAÍBA DO SUL RIVER USING THE QUAL-UFMG METHOD

Background: Due to population growth and increased use of water resources, there has been a need to implement management measures to control and monitor river parameters. Aims: This study aims to demonstrate the application of mathematical modeling using the QUAL-UFMG model for studying nitrogen concentration in the Paraíba do Sul River located in Volta Redonda. Methods: Through mathematical modeling, it is possible to identify areas of greater impact, evaluate the effectiveness of control measures, and propose a strategy to improve water quality and preserve the balance of local aquatic ecosystems. Results: The results obtained during the study showed that the nitrogen parameters and their derivatives are within the pre-established limits set by CONAMA. Discussion: During the modeling, it was observed that there is a tendency for nitrate levels to increase along the points, indicating good self-purification of the river. Organic nitrogen values increase along the points, which is due to the contribution of sewage discharge along the course of the river, as organic nitrogen and ammonia have a physiological origin in domestic sewage. Conclusions: Through the QUAL-UFMG model, it was possible to validate the conducted analyses and create future projections of the water quality in the Paraíba do Sul River along the studied points.
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WITH STRONG PRESENCE AT THE SECOND SOUTHERN SCIENCE CONFERENCE: A HISTORY OF EXCELLENCE IN EDUCATION AND RESEARCH

Background: The Second Southern Science Conference (SSCON 2024) represents a significant milestone in international scientific collaboration, bringing together researchers from twelve nations across multiple continents. The conference, held in Mendoza, Argentina, and co-hosted by the University of Vassouras in Brazil, marked both the 64th anniversary of Universidad de Mendoza and the 20th anniversary of Periódico Tchê Química, demonstrating the growing importance of cross-border academic partnerships. Aim: This study aimed to document and analyze the outcomes and impact of the Second Southern Science Conference, focusing on participation metrics, collaborative patterns, and institutional contributions while highlighting the significance of the hybrid format in facilitating global scientific dialogue. Methods: The analysis involved quantitative assessment of conference participation metrics, including the number of approved papers, author distributions, and institutional representation. The study examined participation patterns across countries and institutions, analyzing collaboration trends through statistical data visualization and comparative analysis of submission rates. Results: The conference achieved significant participation metrics with 65 approved papers and 242 contributing authors, averaging 4 authors per paper. The Universidad Nacional de Córdoba emerged as the leading institution, showcasing its 4 centuries legacy of academic excellence. The analysis revealed strong representation from Latin American institutions, with Brazil and Argentina leading in submissions. Most papers involved 2-5 collaborators, indicating effective research collaboration patterns. Over 500 people participated in the event through both in-person and virtual attendance options. Discussion: The hybrid format successfully facilitated broader international participation and knowledge exchange, which is particularly beneficial for addressing contemporary global challenges. The strong showing from Latin American institutions highlights the region's growing influence in international scientific discourse. The conference's interdisciplinary nature fostered new collaborative initiatives and research partnerships. Conclusions: The conference demonstrated the effectiveness of hybrid international scientific events in fostering global collaboration and knowledge exchange. Areas for improvement were identified, including extended submission timelines and establishment of a permanent management committee. The success of this edition supports the planning of future iterations, with the next edition scheduled to be held in Vassouras, Rio de Janeiro.
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INQUIRY FOR SUITABLE LOCATIONS FOR A DRILLING REGIME AT AN UPSLOPE ROCKY KNOLL OF LAWU ESTATE, WESTERN BYPASS, MINNA, NIGERIA

Background: A client requested that the study group help determine suitable locations for a drilling regime on his lot, located on an upslope rocky knoll in Lawu Estate, Minna, Nigeria. There is no luxury of conducting an unimpeded wide-area survey for this housing Estate, as it is built up almost entirely. Therefore, the constrained area to be surveyed necessitated the adoption of the "electrical drilling," or vertical electrical sounding, mode of the geoelectrical method to satisfy the client's inquiry. Aim: To carry out a purpose-specific survey to pinpoint the best location in a built-up property at the upmarket Lawu Estate that would be suitable for a drilling regime targeted for household consumption. The specific objectives are to determine the subsurface layer structure, to identify fracture zones with potential for water accumulation, and to estimate the depths of potential aquifers. Methods: The survey crew reconnoitered the study area to georeference locations for the VES survey within the 30 m x 20 m lot. Owing to the extensive build-up at this lot, only a four-point traverse along the 30-metric dimension of the building's frontage was demarcated in the northeasterly direction, thereby limiting the survey crew's desire to define an appropriate survey grid. The VES data acquisition followed the "traditional" sequence of Schlumberger array layout measurements, in which the current and potential probes are maintained at the same relative spacing and the whole spread is progressively expanded about a fixed central point. Results: Log-log and pseudosection plots were generated from the acquired data, from which the conventional three-layer structure is deciphered, with a desired 193 Ωm for VES Station 4 at the third layer. Discussion: The acquired and processed data for this study were subjected to a suite of empirical rules-of-thumb procedures for interpreting VES data in the Nigerian Basement Complex geological province, with VES Station 4 showing the most encouraging 100% result. Conclusion: Drilling to a depth of 100 m at Station 4 is recommended based on the identified fractured basement at this depth.
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SOUTHERN JOURNAL OF SCIENCES

The SOUTHERN JOURNAL OF SCIENCES publishes articles in Chemistry, Physics, Mathematics, Biology, Pharmacy, Medicine, Engineering, Industrial Science, Agriculture, and related interdisciplinary areas and is intended to fill a gap in terms of scientific information worldwide. All manuscripts can be published either in English or Portuguese, with tile, abstracts, and keywords in English. At present, there are NO PUBLICATION FEES. Editors will cover web hosting, open access, DOI number, and other service costs.

We have set high standards for the articles to be published by ensuring strong but fair refereeing by at least two reviewers. We hope that this Journal will provide a forum for disseminating high-quality research in chemistry and related areas and are open to any questions and suggestions. Starting in 2020, the SOUTHERN JOURNAL OF SCIENCES will have two issues per year (June and December).

Thank you very much for choosing the SOUTHERN JOURNAL OF SCIENCES to publish your paper!
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