SOUTHERN JOURNAL OF SCIENCES

Background: A new management model for construction and demolition waste (CDW) was proposed for the city of Rio de Janeiro, hence waste the city planning area estimated generation; the results were compared with the data published by COMLURB and SNIS through the statistics tests was proved that CDW had been dispersed, which support the hypothesis that the current model cause dispersion of the rubble. Aim: This study proposes a new management model for CDW to the city, according to regions where occur the higher production of rubble. Methods: The estimation of rubble was obtained through the issued licenses from 2006 to 2020 published by SMPU. The quantification of rubble in the city was carried out by adopting the generation indicator from licensed construction activities. The amount of CDW published by COMLURB and SNIS was compared through statistics tests ANOVA and T-Test, the second period from 2006 to 2020 and 2011 to 2020. To measure the area to implant a CDW recycling plant, criteria from production capacity were used. Results: ANOVA test to data from 2006 to 2020 and 2011 to 2020, according to a confidence interval of 95%, found the P value 0.589 and 0.022, respectively, it was verified that the significant difference is between data from COMLURB and Estimated. The T-test was applied from the same period in data from SNIS and estimated the P values 0.399 and 0.014. Discussion: The data from Estimating between 2006 and 2020 showed the best representation. The Área de Planejamento – AP (Planning Area) 4 was where 50.70% of the total rubble, after the AP 3 with 17.66%, the AP 5 was estimated at 16.59%, last of all, AP 2 and AP 1 were calculated the generation of 8.28% and 6.77%, respectively. Therefore, sizing the CDW recycling producing 361,99.00 tons per year demands an area of 32,397.50 m². Conclusions: It was concluded that the receipt of CDW in transfer stations managed by COMLURB is not allowed; therefore, the need to create a construction waste recycling plant was presented, to this end, it is necessary to have an available area of approximately 32,397.50 m².

Sand casting is a viable waste as an alternative raw material, regarding a good solution in the production of concrete blocks. The use of sand casting to produce concrete blocks is performed by about 80% of the productive capacity of the company considered in this study. Thus, this work aims to make an improvement by applying fuzzy logic. The methodology was applied from the formulation of ranking criteria, which improved the production process. Therefore, after the implementation of the established criteria, was achieved an improvement of about 10%. Thus, the results achieved can help companies, generating alternatives with more excellent reliability and assertiveness. Moreover, Fuzzy is a methodology that provides strong support for decision making, supporting subjective and intuitive criteria.

Background: Drug repurposing offers potential advantages for cancer therapy development, particularly when utilizing medications with established safety profiles and expired patents. While individual repurposed medications have been investigated for oncological applications, comprehensive comparative analyses of research distribution patterns across multiple therapeutic candidates appear limited in the literature. Understanding these patterns may provide insights into research priorities and potential knowledge gaps. Aim: This exploratory study was designed to quantify and compare the volume of scientific literature examining the anticancer potential of eleven selected off-patent medications across different pharmacological classes. Methods: Bibliometric searches were conducted across five databases (Google Scholar, BVS, PubMed, NIH, and Science.gov) using standardized search terms combining each medication name with "cancer" and "cancer treatment." The selected medications included ivermectin, fenbendazole, mebendazole, albendazole, metformin, propranolol, disulfiram, valproic acid, thalidomide, dexamethasone, and hydroxychloroquine. Basic statistical analyses were performed to examine the distribution patterns and correlations within the database. Results: The search yielded 3,226,066 total publications with considerable variation in distribution patterns. Dexamethasone accounted for the largest proportion (1,538,058 publications, 47.68%), followed by metformin (697,172 publications, 21.61%). Some medications with smaller overall publication volumes demonstrated higher proportions of treatment-specific research, such as fenbendazole (87.82%), disulfiram with copper (86.54%), and hydroxychloroquine with zinc (75.21%). The Herfindahl Index indicated a high concentration of research attention (0.2870). Discussion: The findings suggest substantial variation in research attention across the selected medications. While some medications dominate the literature, others with focused treatment-specific research may warrant further investigation. The inverse relationship observed between total publication volume and treatment specificity suggests that research patterns in this field may be more complex than absolute publication counts indicate. Conclusions: This preliminary bibliometric assessment reveals an uneven distribution of research attention among repurposed medications being investigated for cancer applications. These patterns may inform future research prioritization, though further qualitative analysis would be valuable to assess the clinical significance of these quantitative observations.